HEPARANASE-1: FROM CANCER BIOLOGY TO A FUTURE ANTIVIRAL TARGET

Heparanase-1: From Cancer Biology to a Future Antiviral Target

Heparan sulfate proteoglycans (HSPGs) are a major constituent of the extracellular matrix (ECM) and are found to be implicated in viral infections, where they play a role in both cell entry and release for many viruses.The enzyme heparanase-1 is the only known endo-beta-D-glucuronidase capable of degrading heparan sulphate (HS) chains of HSPGs and

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A modified risk assessment scoring system for post laser in situ keratomileusis ectasia in topographically normal patients

Purpose: To evaluate and modify the Randleman Ectasia Risk Score System for predicting post-laser in situ keratomileusis (LASIK) ectasia in patients with normal preoperative corneal topography.Methods: In this retrospective study we reviewed data from 136 eyes which had undergone LASIK including 34 ectatic and 102 normal eyes between 1999 and 2009.

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